Abstract

*Miguel J. Iberio, Rockdrigo M. N and Eraclio Coffman Yunes

AD is the most common age-related neurodegenerative disorder affecting elderly populations over the age of 65. Characteristic symptoms of AD include progressive memory loss, declining cognition, impaired linguistic function, and dementia. Pathologically, the brain exhibits extensive synapse and neuronal cell loss, as well as the appearance of Neurofibrillary Tangles (NFT) and senile plaques, associated with widespread oxidative stress and damage. Recent research suggests that glucolytic enzymes, that is (GAPDH) that has been studied in relation AD, possesses highly diverse, non-glucolytic functions, as its expression and activity are affected by multiple factors. Taking into consideration the multitude of functions GAPDH can carry out under normal conditions, in addition to a variety of sub-cellular locations, it is not surprising that this enzyme is so often affected by disease pathology.