Abstract

Gouado Inocent*, Lehman Leopold Gustave, Some Issa T, Mbouyap Yolande, Pankoui Mfonkeu Joel Bertand, Ejoh Aba Richard and Tchouanguep Mbiapo Felicité

Malaria is an endemic parasitic disease that prevails particularly in warm tropical regions of the world. Micronutrient malnutrition such as vitamin A and iron deficiencies which is a public health problem in Cameroon is usually highly prevalent in malaria endemic areas. Characterizing the relationship between micronutrient status (vitamin A, zinc and calcium) and malaria infection among children in Douala town (Cameroon), serum levels of zinc, calcium and vitamin A, were assayed in a total of 116 Cameroonian children (62 controls and 54 malaria patients infected by Plasmodium falciparum) less than six years old by colorimetric and high pressure liquid chromatography (HPLC) techniques respectively showed a significantly lower vitamin A and calcium concentrations (P < 0.01) among malaria patients (0.8 ± 0.4 µmol/l and 81.3 ± 23.7 mg/l) as compared to the controls (1.1 ± 0.6 µmol/l and 96.3 ± 16.7 mg/ml). Vitamin A, calcium and zinc status were lower in 51.85%, 51.85% and 27.27% of malaria patients respectively. Significant correlations (P<0.01) were observed when the following parameters were coupled: Vitamin A/zinc among infected children (r = 0.01), and vitamin A and zinc among uninfected children (r = 0.415). This study suggests that P. falciparum use vitamin A and calcium of its host for its proper metabolism, leading to a decrease in serum levels of these nutrients.