Abstract

Ariel Lin Yan, Vivian Yang Hsiao , Takeshi N. Hsu and Tsai Huang Yi1,*

Seizure is a common manifestation of advanced non-small cell lung cancer (NSCLC) associated with brain metastasis. Anticonvulsants are usually required in addition to brain irradiation therapy for disease control. Concurrent chemotherapy or target therapy might have drug interactions with anticonvulsants and alter the effectiveness of such drugs. Such drug interactions are rarely recognized in clinical practice. We report a case with NSCLC complicated with brain metastasis in which the initiation of erlotinib treatment resulted in recurrence of seizure due to a decreased blood phenytoin level.