Abstract

Akbarzadeh M*, Moradi F, Dabbaghmanesh MH, Zare Nand Parsanezhed ME

In women with polycystic ovarian syndrome (PCOS), increased prevalence of hypertension and abnormal androgen status is common. The study investigated the degree of hypertension (BP) and hyperandrogenemia in the first degree relatives of women with (PCOS) referred to a clinic affiliated to Shiraz University of Medical Sciences. This is a case-control study in which 107 first degree relatives of women with (PCOS) as case group and 107 individuals as control group were interviewed. Then, the first part of a questionnaire including demographic information was filled in, and the blood pressure measurements and blood samples were obtained to evaluate the serum levels of androgens. The data were analyzed through Chi-square. All statistical tests had 95% confidence intervals and alpha coefficient of 0.05. There was a statistically significant relationship between the mean BP of the experimental and control groups (p≤0.001) but no significant relationship was observed among the brothers. The mean testosterone in the experimental groups was significantly higher than the controls (p≤0.001). Testosterone levels in the parents of the experimental group than control group but no significant relationship between them (p≥0.05). The first degree relatives of women with (PCOS) are probably exposed to the risk of high BP and hyperandrogenemia. Screening for hypertension and other risk factors related to increased androgen (Hyperlipidemia, glucose tolerance, etc.) is essential.