Abstract

Figueroa-Valverde Lauro*, Díaz-Cedillo Francisco, Lopez-Ramos Ma, Garcia-Cervera Elodia and Quijano A. Karen

Experimental and clinical studies suggest that dihydrotestosterone can be associated with changes in blood pressure. In this work, the effects induced by dihydrotestosterone and dihydrotestosteronedihydropyrimidine on perfusion pressure and coronary resistance were evaluated, in isolated rat heart using the Langendorff flow model. Additionally, the molecular mechanism involved in the activity exerted by dihydrotestosterone-derivative was characterized. The results showed that dihydrotestosteronedihydropyrimidine [10-9 mM] significantly increase the perfusion pressure (p = 0.005) and coronary resistance (p = 0.006) in isolated rat heart. Additionally, the activity exerted by dihydrotestosterone-dihydropyrimidine on perfusion pressure [109 to 10-4 mM] was blocked in the presence of nefidepine [10-6 mM].These data suggest that activity induced by dihydrotestosterone-derivative on perfusion pressure and coronary resistance is dependent upon its chemical structure. This phenomenon possibly involves the L-type calcium channel activation through a non-genomic molecular mechanism.