Abstract

Guata Yoro Sy*, Alioune Dior Fall, William Diatta, Malick Gueye, Khady Badji, Emmanuel Bassène and Babacar Faye

The analgesic and anti-inflammatory activity of Cassia sieberiana roots were investigated. Analgesic activity had been investigated using acetic acid induced contortions in mice. The aqueous root extract of C. sieberiana at 300 mg/kg per os showed similar analgesic activity than 100 mg/kg of acetylsalicylic acid (20 ± 1.14 vs 26 ± 1.79 contortions) (ns, p < 0.05). In rat paw oedema model, C. sieberiana aqueous root extract significantly decreased carrageenan-induced oedema. These results showed that aqueous root extract of C. sieberiana possessed both analgesic and anti-inflammatory activities, which have justified their use in Senegal traditional medicine to treat pain and inflammation.