Abstract

Shimada Shinji1*, Tanaka Yasukazu2, Waki Hatsue2, Kon Kazuo2, Iwamoto Machiko2and Maruyama Naoki2

It is quite difficult to treat Alzheimer's dementia, where one of the problems is inadequate absorption of drugs. Revolution in manufacturing drugs is expected by the development of nanotechnology. Animal test was conducted to see whether the Ginkgo bilobaextract processed with nanotechnology changed the function of cerebral cortical synapses and hippocampal nerve action. Rats underwent euthanasia 1 month after nanosized G. bilobaextract administered. Synthesis and release activity of acetylcholine was measured, also the population spike and excitatory postsynaptic potential measured using hippocampal slice. Additionally, measurement with quantum resonance spectrometer was performed for human blood, artery and cardiac muscle. The rats with nanosized G. bilobaextract administered showed a trend of acetylcholine release from cerebral cortical synapses more promoted than the control rats. Also, these rats showed greater amplitude of population spike at hippocampal CA1 pyramidal cell layer than the control rats. Remarkable effect on human blood, artery and cardiac muscle was also indicated with quantum resonance spectrometer. Test result showed that the nanosized particles of G. bilobaextract resulted in easier absorption. However, acetylcholine synthesis is not explained completely, and this is to be one of the research themes in nano-medicine to be solved