Abstract

A. E. M. Saeed1, E. I. Abdelkarim , B. M. Ahmed , K. E. Ibrahim , I . S . A . Hafiz ,M. I. Suliman and O. S. A. Mohammed

Four hundred - 21 days old male Bovans type chicks in 10 groups were infected with Raillietina tetragona cystcercoids. 6 groups treated with the N-alkyl/COOR derivatives of the open lactam form of praziquantel (PZQ ) in oral dose of 20 mg/kg body weight on day 21 and on day 24 post infection. The open lactam form compounds showed an efficacy of 40, 100, 100, 100, 74 and 56% on the first dose and an efficacy of 50, 100, 100, 100, 100 and 100% respectively on the second dose. Histopathological, haematological and biochemical alterations were evaluated, accordingly no serious signs of toxicity were observed in the birds treated with the different compounds tested.