Abstract

Wali U, Saidu Y, Ladan MJ, Bilbis LS and Ibrahim ND

Diabetes mellitus is characterised by increased levels of oxidative stress markers and dyslipidemia, which are implicated in the development of diabetic complications. Antioxidants may be important in delaying the onset of the complications. The current work reports the effect of an antioxidant rich nutriceutical on serum lipid profile and antioxidant status of alloxan induced diabetic rats. The nutriceutical was prepared from onions, garlic, lemon, palm oil and Cray fish in ratio 6:6:2:1:5 respectively. The nutriceutical was administered orally to diabetic rats(wister strains ) age ≥4 months for three weeks with and without treatment with metformin. Twenty four (24) hours after the last administration, blood samples were collected from the rats by cardiac puncture following anaesthesia in chloroform vapour. The effect of supplementation on serum levels of glucose, lipid profile, malondialdehyde, glutathione peroxidase, Cu, Mn, Zn, vitamins A, C and E were assessed. The results indicated that supplementation with the nutriceutical significantly (P<0.05) reduced serum levels of glucose, malondialdehyde, cholesterol, triglyceride and atherogenic index. Supplementation also increased the serum levels of glutathione peroxidase activity, Zn, Cu, Mn, vitamins and HDL-cholesterol significantly (P<0.05). The results suggest that supplementation may reduce the risk of oxidative stress and dyslipidemia associated with diabetes mellitus.