Abstract

E Ulas SAZ, Tugcin Bora Polat and Sarenur Gokben

The present paper describes the role of catecholamine with chromogranin A(CgA) in tumor angiogenesis linked to capacitance relaxation phenomenonl. The capacitance relaxation phenomenon is the observation about the capacitance value which jumps rapidly in cancer cell around 200Hz.It has been established that catecholamine is of recent interest in regulation of angiogenesis. The present paper deals with chromogranin A (CgA), coreleased with catecholamine in plasma in patients suffering from pheochromocytoma(PHEO), multiple endocrine neoplasia (MEN), medullary thyroid carcinoma (MTC), and congenital adrenal hyperplasia(CAH) and patients with others endocrine disorders. The paper also discusses the progressive rise in CgA with catecholamine linked to capacitance relaxation phenomenon. The experimental results of capacitance relaxation phenomenon were given as inputs to a model for correlation with the CgA level and catecholamine. It is to be noted that the model is simulated in MATLAB 7.0. MATLAB allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interface and interfacing with programs written in other languages.