Abstract

Dougnon T . Jacques, Kpodekon T. Marc and Adjagba Marius

The effect of hepatic detoxication with the help of fresh pineapple (Ananas comosus), was evaluated on 28 wistar albinos rats previously intoxicated by DOLIPRANE® containing 20% of paracetamol. Four batches consisting, each them of 7 animals were formed. Batch n° 1, was neither intoxicated nor treated. Batch n° 2 was intoxicated for 2 weeks at the rate of two two (2) grams of DOLIPRANE® per kilogramme of live weight per day, then treated for 4 weeks with 13 mg of fresh pineapple per kg of live weight per day. Batch n°3 was intoxicated in the same way as batch n°2, but received 26 mg of fresh pineapple during 4 weeks. Batch n°4, was intoxicated for two weeks with the same daily amount of DOLIPRANE® and did not receive any treatment with pineapple. The rates of Alkaline Phosphatase (ALP), Glutamate Oxaloacetic Transaminase (GOT) and Glutamate Pyruvate Transaminase (GPT) enzymes were ganged. As for batch n°4, the values of those enzymes underwent a highly significant increase on the threshold of 0.1% when compared with the other three batches. ALP concentrations decreased from 406.67 ± 7.17 to 223.67 ± 3.28 for batch n°2 after the treatment with the pineapple. Concerning the GPT, value significantly decreased, passing from 242.67 ± 31.67 to 106 ± 2.31 for batch n° 2. As for the GOT, its rate passed from 184.67 ± 3.75 to 117.33 ± 2.73 for batch n°2, without any significance level on the threshold of 5%, comparing batches n° 2 and n°3. It emerges from this study that overdosing of DOLIPRANE® (2 g/kg of live weight) affected the biochemical level, the normal functioning of the liver of the wistar rats intoxicated per os. Fresh pineapple had a reconstructive effect on the hepatic metabolism of the intoxicated rats.