Abstract

Bhupinder Singh Sekhon

Design of agrochemical active ingredients is a multidimensional task. Co-crystals are crystalline compounds that contain two different molecules that pack together in a fixed way. Co-crystallization can be used as a reliable technique to form alternative solid forms of agrochemical actives, and co-crystals do indeed have potential to increase the apparent solubility of compounds with poor dissolution properties. No marketed agrochemicals have been actively developed as co-crystals so far, but several companies are actively investigating them. Use of the Cambridge Structural Database which screens potential co-formers for a given active compound to find suitable, strongly interacting co-crystal partners is desirable.