Abstract

Nilgül Akalin, Md, Cemal Bes, Md, OzlemHarmankaya, Md, Kayhan Ertürk, Md, Yıldız Okuturlar, Md and Baki Kumbasar, Md

We aimed to assess the presence and clinical effect of inflammation in the patients with familial mediterranean fever who follow-up treatment regularly. All the patients were measured with C-reactive proteine, homocysteine, fibrinogene levels and biochemical parameters; the presence of atherosclerotic plaque was investigated in the carotid intima artery. Leucocyte, C-reactive protein and fibrinogene levels were found to be significantly higher in the familial mediterranean fever group patients. Homocysteine levels and the presence of atherosclerotic plaque in the carotid intima artery were found to be significantly lower in the familial mediterranean fever group patients. Increasing the odds ratio for homocysteine was found to be related to dialysis treatments. The correlation between the presence of proteinuria, microalbuminuria, inflammation and the presence of atherosclerotic plaque in the carotid intima artery were not determinate to the familial mediterrian fever group of patients. We demonstrated that inflammation might be present continuously despite regular treatment in the patients with familial mediterrian fever and that this inflammation can be the main reasons or contributory factor to the complications of the disease.