Abstract

Ouédraogo SM, Sourabié Y, Sanodji N, Sawadogo S, Barro M, Ouattara A.B.I Traoré Y, Nacro B

Objective: To study the determinants of non-immunological response with HIV infected patients on antiretroviral treatment in Centre Hospitalier Universitaire Souro SANOU (CHUSS), Bobo – Dioulasso. Methods: It was a historical cohort study from 2010 to 2014. We included all patients aged 1-18, infected with HIV and on antiretroviral (ARV) treatment followed at the pediatric day hospital and the Internal Medicine of CHUSS and non responders (INR) to ARV treatment. The INR was evaluated by the numeration of CD4 + cells on a flow cytometer (FACSCount V1.5). HIV patients were apportion according to the regimens received. (AZT + 3TC + NVP, AZT + 3TC + EFV; AZT + 3TC + LPV / r and AZT + ddI + EFV). A total of 351 children were followed clinically and biologically respectively in the pediatric departments of internal medicine and laboratory. The average age of patients was 12 years ± 5.6 with extremes from 1 to 18 years. The prevalence of immunological non-responders (INR) in our cohort was 9% (31/351) on antiretroviral treatment over an average period of 3.5 years. Of these, 3.41% were at WHO Stage C. Among the determinants to INR, males were found to be 5.98% (21/351) whose CD4 rate was 14%, type of ARV molecule, type of HIV. With 13% of INR, were prescribed AZT + 3TC + NVP regime. The average weight of the patients their age, and the average CD4 rate at treatment initiation were not found as determinants to INR. Conclusion: All the INR was HIV1 and 13% were under AZT + 3TC + NVP regimen, the possibility of existence of stem CXCR4 is not excluded even if we had not been able to explore it due to financial constraints.