Abstract

Atamgba Agbor Asuk*, Ofem Effiong Ofem, Kazeem Olasunkanmi Ajeigbe,Mbeh Ubana Eteng and Kingsley Omage

This study was aimed at evaluating the impact of wine obtained from a blend of five fruit extracts on some haematogical indices of male and female albino Wistar rats. Seventy male and female rats were randomly divided on the basis of body weight and sex into seven study groups. Group I (normal control) received normal diet and distilled water only, while the other groups except VI and VII (which had low doses of standard red and cashew wines respectively) received either low (corresponding to four standard drinks) or high (six standards) doses of the respective multi-fruit wine samples. Haematological indices determined showed that Hb and RBC values were not altered in both sexes compared with the control. The WBC values of all the test groups of female and male rats decreased significantly (P<0.05) compared with the normal control except H-MFWA (high dose of multi-fruit wine with additives) in females which compared well with the normal control. General decrease in MCV values of females and increase in males were significant (P<0.05) in some cases when compared with the normal control. Results of the investigation showed that sex differences associated with the handling of alcohol toxicity in the serum exist among male and female rats with the administration of multi-fruit wine. It also suggests the possible role of phytochemicals and wine additives in influencing the outcome of certain haematological parameters.