Abstract

Omayma A Ragab, El-sonbaty SM, Aziza SA and Aboelftouh AE

Functional food enters the concept of considering food not only as a necessity for living but also as a source of mental and physical well-being. The anti-proliferative effects of fermented soy suggested the need of low dose of gamma radiation in order to achieve an optimal therapeutic effect. This study investigated the potential chemotherapeutic effects of orally administrated fermented soy milk (FSM) with low dose of gamma radiation on mammary carcinogenesis induced by exposure to N-methyl-N-nitrosourea (MNU). There was significant immunomodulatory effect of FSM on the reduction of WBC count caused by gamma radiation or MNU. Also FSM showed ameliorative effect on GPx, SOD and CAT enzyme activities and on lipid peroxidation and TNF-α level compared to rats exposed to radiation or MNU. FSM and irradiation markedly elevated GSH content. Combined treatment of FSM and radiation ameliorated MNU effect on cell cycle phases Go/1,S,G2/M. pretreatment with FSM and gamma radiation markedly conclusion, Consumption of FSM synergizes with exposure to low doses of gamma radiation which was found to have a protective and ameliorative effect from carcinogenesis and oxidative stress induced by MNU