Abstract

Haibin Ma1*, Huiying Lin2 , Hai Feng 2 and Ramesh Putheti3

The study aims at assessing the effects of angelica polysaccharide (APS) on hepatocytes apoptosis in rats induced by exhaustive exercise. The exhaustive-exercise rat model was established by dividing 32 male wistar rats into four groups randomly. The groups were the normal control group (NC), exhausting exercises control group (EC), low dose APS group (LA) and high dose APS group (HA).The immunohistochemistry staining was used to test the protein expression of Bax and Bcl-2 in liver tissue in rats. Then the Bax/Bcl-2 ratio and hepatocytes apoptosis in each group was analyzed. The result showed that the expression of Bax in rats' liver tissue was decreased, Bcl-2 was increased and the ratio of Bax/Bcl-2 was decreased when exposed to exhaustive exercise after being force-fed with angelica polysaccharide by gastrogavage. Angelica polysaccharide could counteract the hepatocytes apoptosis in exhaustive-exercised rats' liver tissue with better results gotten at high-dose (600 mg/kg·bw).