Abstract

Omage Kingsley, Onoagbe, O. Iyere, Erifeta O. Georgina, Uhunmwangho S. Esosa, Ajeigbe O. Kazeem3 and Amegor O. Frank

In this study, the effects of aqueous root extract of TRECULIA AFRICANA on blood glucose, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and body weights of both STZ-induced diabetic and normal rats were investigated. Oral administration of aqueous root extract of TRECULIA AFRICANA at a dose of 200 mg/kg body weight per day, for a period of 14 days, caused a significant (p < 0.05) reduction in the blood levels of glucose, triglycerides, total cholesterol and LDL-cholesterol of both diabetic and normal rats. This dose also caused a significant (p < 0.05) increase in the HDL-cholesterol concentrations and body weights of both diabetic and normal rats. These effects portend the effectiveness of the plant in the management of diabetic conditions and hyperlipidemic states.