Abstract

Manzoor Rather , Rohtesh S. Mehta *, Shalini Vijaykumar , Orville Domingo and Colette D. Terry

Calciphylaxis is an infrequently observed disease ob-served in end stage renal disease (ESRD) patients with an incidence of about 5% and carries a high mortality of up to 80% despite treatment (Rogers and Coates, 2008). Its basic pathophysiology is the deposition of calcium in small- and medium-sized vessel walls. The diagnosis may be challenging in the presence of other confounding factors such as prior radiation therapy to the specified part involved and patients on warfarin who can develop skin necrosis. A comprehensive history and physical exami-nation provides clue to the diagnosis, while biopsy is the confirmatory test. We describe a case of an end-stage renal disease young female with prior history of breast radiation treatment that was on warfarin therapy, presented with a painful necrotic breast.