Abstract

Shehua Cao*, Huanping Shang, Weibing Wu, Jingrong Du and Ramesh Putheti

To study the anti-athletic fatigue effects of Schizandra chinensis aqueous extracts (SCAE), Forty Kunming male mice were randomized into 5 groups (CG, LDG, MDG, IHDG and HDG) equally based on body mass after one week adoption. The control group (CG) was given distilled water and LDG, MDG, IHDG and HDG were given various doses of SCAE (15, 30, 50 and 80 mg/kg) for 28 consecutive days, respectively. Swimming time, lactate, blood urea nitrogen (BUN) and hemoglobin (Hb) concentration were measured in the forced swimming treated mice. Results showed that SCAE had significant anti-athletic fatigue effects on mice. It extended the swimming time, increased concentration of the Hb, prevent the increase in lactate and BUN concentrations. In addition, acute toxicity studies revealed that SCAE did not exhibit any toxic symptoms in the limited toxicity evaluation in mice.