Abstract

Vagner Rodrigues Santos*, João Luis Duval Cândido da Silva, Sérgio Monteiro Lima Jr, Felipe Alcântara Braga, Mariana Passos De Luca, Vladimir Reimar A. Souza Noronha, Evandro Guimarães Aguiar and Márcio M. Mattos

Experimental chronic inflammation in periodontal actinomycosis was studied with INCQS standard Actinomyces israelii infected mandibula in Swiss/NIH mice (n = 45), male and female with 21 days of age. Tissue responses of the experimentally induced chronic inflammation were investigated in mice by clinical and light microscopy. After anesthetization, the animals were inoculated in paraperiosteal periodontium anterior mandibula with 108 UFC/mL A. israelii (n = 45) associated with sodium alginate gel particles. The animals had been evaluated clinically and microscopically at 1, 3, 7, 15, 21, 30 and 45 days after inoculation. Chronic inflammation was induced in all the mice when compared to the control animals. As such, both groups had normal general health throughout the study. In the control mice (n = 10), no lesions were noted. However, the clinical and histopathology evolutions of actinomycosis lesions had been observed and are discussed in this work.