Abstract

N. T. Al- alusi*, F. A. Kadir, S. Ismail and M. A. Abdullah

This study has carried out to evaluate the antibacterial effect and the interaction between Tinospora crispa and Swietenia mahagoni extracts against resistant strains of Methicillin-resistant Staphylococcus aureus (MRSA). The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) were determined in the setting of clinical MRSA isolates. Separated and mixture forms of T. crispa and S. mahagoni extracts were assayed to determine their antibacterial activity against eight clinical MRSA isolates. The extracts of T. crispa and S. mahagoni in separated forms were effective against MRSA strains. However, no interaction was found in the two plants combination. In conclusion, T. crispa and S. mahagoni are potential as anti MRSA agents, but the mixture of T. crispa and S. mahagoni has no synergism against MRSA strains.