Abstract

Sarra Klai1 *, Najiba Fekih-Mrissa1 , Mourad Bouricha2 and Nasredine Gritli1

Vascular disease in pregnancy is a rare event. Inherited risk factors for vascular disease include factor V Leiden, prothrombin, methylenetetrahydrofolate reductase point mutations and Antithrombin, protein C and S deficiencies. Recent studies suggest that there is also a link between these inherited ththrombophilias and adverse pregnancy complications such as fetal loss as well as venous thromboembolism. Here we describe 2 young patients with cerebrovascular thrombotic events whose only risk factor was genetic thrombophilia. In patients, complete clinical evaluation and laboratory investigations, including a thrombophilia workup and full radiological assessment, were performed. Recently genetic thrombophilia was reported in association with venous thromboembolism and various complications of pregnancy. Although it is rare, thrombophilia must not be misdiagnosed.