Abstract

Sibel Koçak Yucel MD,

Drug-induced acute interstitial nephritis (DI-AIN) is an important cause of reversible acute kidney injury.While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with druginduced AIN,few reports have been made on the involvement of other analgesics.Side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) most commonly affect the gastrointestinal tract and the kidney.This case report describes the first case of biopsy proven interstitial nephritis associated with acute renal failure in a patient treated withlornoxicamthe non�?�selective inhibitior of cyclo�?�oxygenase�?�1 and �?�2. She presented with clinical findings of acute renal failure that required dialysis.The renal biopsy showed acute interstitial nephritis with a prominent eosinophilic infiltrate in the interstitium.She recovered normal renal function three weeks after cessation of lornoxicam and use of a corticosteroid (1 mg/kg/day).A course of oral prednisolone (1 mg/kg/day) was commenced andrapidly tapered to zero within three weeks.The renal function improved, and the patient was discharged with a creatinine of 0,75mg/dl (67 μmol/L).In general, the prognosis for drug-induced AIN is good and at least partial recovery of kidney function is normally observed. Early recognition is crucial because patients can ultimately develop chronic kidney disease