Abstract

R. Ravichandran

Gymnemic acids, the main phytoconstituents of Gymnema sylvestre possess potential natural pharmacological activities like supression of taste sensitivity to sweetness, inhibition of intestinal glucose absorption and lowering the plasma glucose levels. Nanonisation of active drug components are shown to improve their physiological action. In this study, nanoparticulate formulations of gymnemic acids prepared were studied for its Pharmacokinetic and Pharmacodynamic behavior compared with marketed product. The nano-formulation exhibited significant anti-diabetic activity compared to marketed product.