Abstract

M. O. Afolabi, G. O. Adegoke and Mathooko, F. M

Phytochemical screening of methanol extracts of the leaves, flowers, stems and roots of Aframomum danielli revealed the presence of alkaloids, cardenolides, flavonoids and polyphenols. Fractions from the extracts were tested for antioxidant activities and lipoxygenase enzyme inhibition. Flower fraction FF5 and leaf fraction LF4, which were the most potent fractions, gave antioxidant effectiveness values of 85.32 ± 0.27 and 53.92 ± 0.03%, respectively on 1,1, diphenyl 1,2 picrylhydrazyl (DPPH) free radicals at a level of 750 µg/ml. The lipoxygenase enzyme inhibition at 750 µg/ml was 87.11 ± 5.13% (FF5) and 82.55 ± 2.62% (LF4). All fractions inhibited Bacillus subtilis, staphylococcus aureaus, Escherichia coli, Salmonella enteriditis, Candida albicans and Aspergillus flavus.