Abstract

C. I. Mboto1*, M. E. Eja1, A. A Adegoke3, G. D. Iwatt2, B. E. Asikong1, I. Takon1, S. M. Udo1and M. Akeh4

Warm water extracts of the leaves of Garcinia kola and Vernonia amygdalina suspended in honey traditionally employed for the treatment of post circumcision wounds, fresh wounds and chronic skin ulcers was prepared and evaluated for its phytochemical properties and antimicrobial activities. The phytochemical analysis of the preparation revealed the presence of polyphenol, reducing sugars, tannins, glycoside, alkaloids, saponins, flavonoids and anthraquinones. Neat (100%) concentration of preparation inhibited the growth of Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and Candida albicans. At 50% concentration, the growth of P. aeruginosa while S. aureus and K. pneumoniae were inhibited while at 25% concentration only P. aeruginosa was inhibited. The result suggests that the preparation exhibited significant in vitro antimicrobial activity against common wound isolates and may be employed for the routine treatment of wounds and sepsis as an alternative to antibiotics chemotherapy.