Abstract

Fadel M. A1*, R. El-Gebaly1, A. Aly1, A. Sallam2, O. Sarhan3 and H. Eltohamy4

The aim of the present work is to study the therapeutic effects of 4.5 Hz of electromagnetic radiation as a preventive agent on the metastasis of Ehrlich tumor which occurred in some organs. The tumor was implanted intramuscularly in the left thigh of mice. Sixty female Balb/c mice were used, twenty as normal group and the other forty were divided equally into 2 groups namely A and B. Group A was the control while group B was whole body exposed to square amplitude modulated waves (QAMW) of frequency 4.5 Hz for a period of 40 h at a rate of 4 h/day starting day 11 post tumor implantation. At the end of the experiment liver, kidney and spleen were excised for all groups. Kidney and spleen were subjected to histological examination. Fragments of the freshly excised liver were subjected to histopathological examination and the other parts were used for dielectric measurements. The results of this work indicate that the treatment of Ehrlich tumor by QAMW caused a decrease in the percentage of metastasis, also there was a decrease in the values of relative permittivity, conductivity and dielectric loss of group B as compared with group A. The statistical methods and analysis for evaluation of the results were done by calculating arithmetic means and standard deviations for percentage of metastasis and dielectric measurements. It may be concluded that whole body exposure of the animals injected with Ehrlich tumor to 4.5 Hz QAMW can inhibit tumor growth in secondary sites or distant organs and can be used as preventive agent to murine metastatic development.