Abstract

Siti Jakob, Sari Dewa and Ismu Hamid

This study showed the profile of retinoblastoma in East Java, Indonesia and correlations between important factors for retinoblastoma based on the stage of malignancy and pedigree. This is a retrospective study based on hospital medical record. Fourty four patients were diagnosed of retinoblastoma by histopathology examination. The classification of pedigree was determined by unilaterality/bilaterality and family history of retinoblastoma. IRSS (International Retinoblastoma Staging System) classification was used to determine the stage of retinoblastoma, that is, intraocular, extraocular and metastasis stage. The mean age of patients was 44.64 months and most patients were in the age group of 60-119 months (22.72%). The study showed 38 (86.36%) cases of unilateral retinoblastoma and 6 (13.64%) cases of bilateral retinoblastoma. Retinoblastoma surface in patients mostly at stage III-a with the total of 27 (61.36%) cases and stage I or II each 6 (13.64%) cases. Pedigree classification showed 1 (2.27%) familial hereditary retinoblastoma patient, 6 (13.64%) sporadic hereditary retinoblastoma patients, and 37 (84.09%) patients of non-hereditary retinoblastoma. Spearman correlation test between age and IRSS show a significant results at stage III-a (rs = 0,785, p=0.002). Most patients with unilateral retinoblastoma (84.09%) were non-hereditary retinoblastoma survivors and patients with bilateral retinoblastoma (15.91%) were hereditary retinoblastoma which include familial and sporadic retinoblastoma.