Abstract

Aliando Andriana*, Sri Mulyani Syarief and Krisdayanti Nike

Global prevalence of diabetes mellitus is increasing all over the world, resulting in higher prevalence of diabetic complication. Diabetic nephropathy is the most frequent complication suffered by diabetic patients. Phaleria macrocarpa (Scheff.) Boerl (PM) consist of active substance s which have antidiabetic properties. This study aims to evaluate the protective effect of PM pericarp extract on renal histological changes of alloxan-induced diabetes. Twenty five male albino (Sprague Dawley) rats were divided into five groups (of five each): normal control; diabetic; diabetic + metformin 100 mg/kgBW; diabetic + PM methanolic extract 250 mg/kgBW and diabetic + PM water extract 250 mg/kgBW. Diabetes was induced by alloxan monohydrate 150 mg/BW intraperitoneally. PM extract and metformin (as comparison group) was administered to diabetic rats for three weeks and at the end of the study, rats were sacrificed to obtain their kidneys for routine staining. Treatment with PM extracts (methanolic and water) and metformin significantly reduced glomerular hypertrophy, though the glomerular area of these groups was lower than that of the diabetic group (p < 0.01). Treatment with PM extract (methanolic and water) significantly reduced glomerulosclero sis, which showed a lower score of glomerulosclerosis degree (p< 0.01), and was still observed to be lower if compared with metformin (p < 0.01). It was concluded that PM extract re stored glomerular hypertrophy and improved glomerulosclerosis in alloxan -induced diabetes.