Abstract

Alexandra I. Brezhnev

The aim of this work is approbation of the pathogenetically substantiated psycho-immunological rehabilitation of advanced cancer patients with psychogenic medical history. 17 advanced cancer patients (with 6 various types of cancer) took part in this study. All psycho-emotional disorders were diagnosed clinically and psychometrically (SCL 90). The treatment of signs and symptoms of mentioned disorders included hypnotherapy and psychotropic drugs. The specific anti-tumor activity of the immune system was assessed by the delayed type hypersensitivity skin reaction on the tumor-associated antigens. An activation of specific anti-tumor immunity was provided only after stable clinical effect of psycho-correction by specially developed methods of epicutaneous and modified extra-corporeal activation. The effective treatment of psycho-emotional disorders had a direct correlation with spontaneous increase in specific anti-tumor activity of the immune system (p < 0.0008). The catamnesis showed that only 5 advanced cancer patients, who were provided with whole course of psychoimmunological rehabilitation survived for 1.5 years and up to 7 years after psycho-immunological rehabilitation. The rest 12 patients died. This study showed some clinical opportunities of positive influence of special psycho-immunological rehabilitation on to the course of a disease of advanced cancer patients with psychogenic medical history.