Abstract

Mohammad Ali Esmaeili*, Ali Sonboli , Mohammad Reza Kanani and Heibatollah Sadeghi

Oxidative stress plays an essential role in the development of alcohol liver disease. The present study represents the protective effect of a polyphenolic rich extract of Salvia sahandica against liver and kidney damages in alcoholinduced oxidative stress. Measurement antioxidant activity by scavenging of 1,1-diphenyl-2-picrylhydrazyl radical showed that methanolic extract of S. sahendica possesses the highest antioxidant activity. Treatment of experimental rats with ethanol for one month showed an increase in activities of liver marker enzymes, lipid peroxidation marker (TBARS) with significantly lower activity of enzymatic and non- enzymatic antioxidants in rat liver and kidney compared to those in normal rats. Treatment alcohol rats with S. sahendica at a dose of (0.1 g/kg) significantly reduced the level of lipid peroxidation and liver marker enzymes and restored the enzymic and nonenzymatic antioxidants levels in liver and kidney of treated rats. The results of this study strongly indicate that S. sahendica has potent hepato-protective effect against alcohol induced tissues damage in experimental animals. This study also suggests that possible mechanism of this activity may be due to the presence of flavonoids and phenolics compound(s) in the methanolic extract of S. sahendica which may be responsible to hepato-protective activity.