Abstract

Igor V. Ukrainets *, Olga V. Gorokhova , Xeniya V. Andreeva and Galina Sim

The simple methods for obtaining have been suggested and the synthesis of new hydroxyalkylamides of 1-(2-cyanoethyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid and their derivatives has been carried out by alcoholic hydroxyl. The peculiarities of the spatial structure of the given group of substances have been considered by an example of 3-isopropoxypropylamide. The research results of the analgesic activity of all the compounds synthesized are given; they confirm the expediency of searching new painkillers among quinoline-3-carboxamides. According to the results of pharmacological tests for in-depth study recommended (3-chloropropyl)-amide of 1-(2-cyanoethyl)-4- hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid.