Abstract

Wencheng Xue, Lianqing Zhou, Meiling Chu, Jin Yang, Lu Wang, Dongya Meng*

This study was implemented to analyses the association between the regional rates of antimicrobial resistance in Acinetobacter baumannii (A. baumannii) isolates and antimicrobial consumption in the hospital districts. The data on the consumption of antimicrobial for systemic use in Liao-Ning North Hospital were obtained from 2005 through 2009. Consumption data were compared with antimicrobial resistance in all isolates of A. baumannii. Statistical significance was defined as p value < 0.05 for the corresponding correlation coefficient. With the increase of drug resistance, A. baumannii isolation rate increased significantly, the proportion of A. baumannii infections in the composition of bacteria was also significantly increased (from 2.3% in 2005 year to 17.6% in 2009 year). Yearly rates of resistance to meropenem, cefepime, ceftazidime, piperacillin and amikacin were significantly associated with meropenem or levofloxacin (P < 0.05) consumptions in the same year, while consumption of cefepime, ceftazidime and amikacin had no apparent association with resistance. The consumption of Meropenem and levofloxacin significantly correlated with resistance of Meropenem, levofloxacin, cephalosporins, amikacin and piperacillin in A. baumannii. The formation of bacterial clones and being prevalent in the local context may be the ideal model for studying antibiotic usage and resistance development.