Abstract

*Zhuo Zetian, Jiang S. Kar-wai and Guan V. Salim

This study was to explore the relationship between bacterial vaginosis and cervical dysplasia. Vaginal discharge gram stain, liquid-based thinlayer cystoFast test (TCT), human papilloma virus (HPV) types 16, 18 test, colposcopy and directed biopsy were performed among 46 patients with cervical dysplasia served as investigate group and 100 patients with cervicitis served as control group. There was statistically significant increase in the incidence of bacterial vaginosis among cervical dysplasia group (52.18%) compared with control group (10.0%) (P<0.05). Their human papilloma virus (HPV) 16, 18 positive rates were 60.9 and 3% respectively (P<0.05). Human papilloma virus (HPV) types 16, 18 and bacterial vaginosis co-infection incidence were 41.3 and 0% respectively (P< 0.05). Both human papilloma virus (HPV 16, 18) and bacterial vaginosis (BV) negative results were 28.3 and 87.0% (P<0.05). Logistic regression test indicated that human papilloma virus (HPV) 16, 18 and bacterial vaginosis were independent risk factors for cervical dysplasia. Bacterial vaginosis facilitates the infection of HPV type 16, 18 and thus enhances development and progression of cervical dysplasia.