Abstract

Valery Gafarov, Mikhail Voevoda, Elena Gromova, Vladimir Maksimov, Igor Gagulin, Nikolay Yudin, Almira Gafarova, and Tatiana Mishakova

The purpose of the study was to investigate prevalence of hostility, risk of arterial hypertension (AH), myocardial infarction (MI), and stroke, and genetic traits in open male population in Novosibirsk (Siberia, Russia). Random representative sample of 25–64-year-old men was examined in the WHO MONICAPsychosocial program in 1994. Hostility level was assessed by Cook-Medley test. Genotyping of VNTR polymorphisms of DRD4 and DAT genes was performed. From 1994 to 2008, all first-time cases of AH, IM, and stroke were registered among individuals without previous CVD. The level of hostility was 76.9%. Compared with control, 5-year MI risk was by 2.57 times higher (95%CI 1–6.1; p<0.05) in men with hostility; hostility led to 3.2-fold increase of IM risk in older age group (95%CI 1–10; �?<0.05). Hostility did not increase AH and stroke risks. Dopamine receptor subtype D4 (DRD4) genotypes 4/6 and 4/7 were associated with high hostility levels; genotype 4/4 was associated with moderate and low hostility levels. No associations with DAT genotypes and alleles were found. Open population of 25–64-year-old men of Novosibirsk showed high hostility prevalence predictive of IM risk. Hostility did not affect AH and stroke risks and was associated with certain VNTR polymorphisms of DRD4 gene.