Abstract

Valery Gafarov,1,2 Mikhail Voevoda,2,3 Elena Gromova,1,2 Vladimir Maksimov,2,3 Igor Gagulin,1,2 Nikolai Yudin,3 Almira Gafarova,1,2 and Tatiana Mishakova3

Objective of the study was to elucidate prevalence rates of vital exhaustion (VE), its effects on cardiovascular disease (CVD) risks, and genetic traits in open population of 25–64-year-old men in Russia/Siberia (Novosibirsk). Random representative sample of 25–64-year-old men was studied in a framework of WHO MONICA-Psychosocial Program (MOPSY). Maastricht Questionnaire (MQ) was used to assess VE. Genotyping of VNTR polymorphisms in DRD4 and DAT genes was performed. All new cases of arterial hypertension (AH), myocardial infarction (MI), and stroke were registered in people without CVD from 1994 to 2008. Data showed that VE rate was 66.8% in study population. Hazard ratio was significantly increased (AH: HR = 3.2; MI: HR = 2.7; stroke: HR = 3.2) in men with VE compared with VE-free individuals during the first five years of observation. Multifactorial modeling showed that VE together with concomitant social gradient determined development of AH, MI, and stroke in open male population. Allele 7 of DRD4 and genotype 9/9 of DAT gene were associated with high level of VE. Open population of men showed high level of VE, predictor for risk of developing CVD. Vital exhaustion was significantly associated with certain VNTR polymorphisms of DRD4 and DAT gens.