Abstract

Nataraja Thamizh Selvam*, Venkatakrishnan V and Damodar Kumar S

In recent years, oxidative stress and free radicals have been implicated in various diseases. Syzygium jambos, is a plant used by traditional physicians in Kerala, India for various ailments including wounds, ulcers and dermatopahty. The present study was undertaken to assess the antioxidant activity of methanolic extract of S. jambos leaf in paracetamol intoxicated Wistar albino rats. The rats were divided in to five groups of six animals each, categorized as healthy control group, disease control, standard group and two test groups. The test extract was administered in two difference doses as 100 and 200 mg/kg/ b.wt. The biochemical parameters SGOT, SGPT levels in blood and antioxidant profiles including of superoxide dismutase, catalase and glutathione levels in blood and different tissues (liver, kidney, heart) were evaluated. The results showed elevated levels of antioxidant enzymes in blood and tissues in treatment groups suggesting significant antioxidant activity.