Torsade de pointes in a patient with bronchopenumonia and atrial fibrillation treated with clarithromycin.

Abstract


Lihua Fang, Chung-Jen Huang*, Hwang-Daw Hua and Chung-Hsin Huang

Clarithromycin is a macrolide antibiotic widely used in pulmonary infection and Helicobacter pylori eradication. QT prolongation on an electrocardiogram with torsade de pointes is an uncommon fatal side effect. We report a patient with atrial fibrillation and congestive heart failure who develops torsade de pointes after clarithromycin, tamoxifen, amoxillin/clavulanate, digoxin and verapamil use, and discuss the pharmacological mechanism and prevention.

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