Abstract

Canan Demir* and Mehmet Demir

Vitamin D deficiency is associated with several adverse health outcomes and vitamin D appears to have systemic antimicrobial effects that may be crucial in a variety of both acute and chronic illness. In our study we compared 25- hydroxy vitamin D levels, between chronic hepatitis B Virus infection, natural immunized persons and control groups. Thirty five chronic hepatitis B virus infection patients (Group I) and thirty natural immunized persons (Group II) and thirty healthy adult were included in this study. Hepatitis markers were determined by commercial kit based on chemilumminesans assay. Routine biochemical parameters, hepatitis B virus serology, hepatitis B virus-DNA, 25-hydroxy vitamin D and parathormone levels were performed. Baseline characteristics of the study groups were comparable. Group I patients had a lower vitamin D level than group II and the control group (7.65±4.19; 12.1±7.13 and 14.17±9.18ng/ml, p<0.001, respectively). Additionaly group I patients had a higher parathormone level than group II and the control group (88.21±34.2; 75.14±23.4 and 74.16±20.15ng/ml, p=0.001, respectively). Also vitamin D levels were correlated hepatitis B virüs-DNA levels. In the hepatitis B virus infected patients, diminished vitamin D levels may be an indicator of the presence of replication and poor prognosis