Abstract

Tazi

Waldenström’s macroglobulinemia (WM), a lymphoplasmacytic lymphoma, is characterized by neoplastic proliferation of B lymphocytes and excessive production of monoclonal immunoglobulin M (IgM). The leading clinical features are lymphoadenopathy and/or splenomegaly, anemia and hyperviscosity syndrome. Cognitive impair-ment due to central nervous system infiltration by lymphoplasmocytoid cells (Bing-Neel syndrome) has been rarely reported (Civit et al., 1997).