Sinethemba H. Yakobi

Publications

• Review Article   
  Current strategies and future directions associated with to the potential of antimicrobial-resistant Neisseria gonorrhoeae vaccine development to rapidly reduce infection
  Author(s): Sinethemba H. Yakobi* and Ofentse J. Pooe
  
  Gonorrhoeae, a sexually transmitted disease caused by the gram-negative diplococcus Neisseria gonorrhoeae, continues to be a major global health problem despite efforts to eradicate it. Neisseria gonorrhoeae is the second most common bacterial sexually transmitted disease in the world. This pathogen has developed resistance to all presently licensed drugs, and multidrug-resistant strains have been detected globally. The World Health Organization (WHO) currently recommends a combined therapy of ceftriaxone and azithromycin. However, when resistance to azithromycin and ceftriaxone develops, treatment failure has been documented. The only effective method to limit the spread of gonorrhoeae is protective vaccination. Previous studies investigated the immunogenicity of novel vaccine formulations based on inactivated whole-cell gonococcal microparticles loaded into soluble.. View More»
  

  Abstract PDF